Goal characteristics predict the occurrence of goal-related events through belief in future occurrence.

While previous studies have highlighted the role of episodic future thinking in goal pursuit, the underlying cognitive mechanisms remain unexplored. Episodic future thinking may promote goal pursuit by shaping the feeling that imagined events will (or will not) happen in the future - referred to as belief in future occurrence. We investigated whether goal self-concordance (Experiment 1) and other goal characteristics identified as influential in goal pursuit (Experiment 2) modulate belief in the future occurrence of goal-related events and predict the actual occurrence of these events. Results showed that goal self-concordance, engagement, and expectancy had an indirect effect on the actual occurrence of events, which was (partially) mediated by belief in future occurrence. The mediating role of belief supports the view that belief in future occurrence when imagining events conveys useful information, allowing us to make informed decisions and undertake adaptive actions in the process of goal pursuit.

Effects of past and future autobiographical thinking on the working self-concept.

While the role of autobiographical memory in self-representation is well established, the identity function of future thinking has received much less attention. Yet, most people commonly imagine future events that convey meaningful information about the person they wish or expect to become. In three experiments, we assessed the extent to which thinking about such self-defining future events influences the current content of self-representation (i.e., the working self-concept). Participants were asked to think about either a past or future self-defining event, or a control topic, before describing aspects of their identity in the form of "I am" statements (Experiments 1 and 3) or completing scales assessing self-related dimensions (Experiments 2 and 3). We found that thinking about a future self-defining event led participants to conceptualise themselves more in terms of their psychological traits, as did thinking about a past self-defining event. Furthermore, thinking about a future self-defining event increased the sense of present-future self-continuity, whereas thinking about a past self-defining event increased the sense of past-present self-continuity. These results suggest that self-representations are fuelled not only by autobiographical memories, but also by projections into the future.

Changes in the levels of free sialic acid during ex vivo lung perfusion do not correlate with pulmonary function. Experimental model.

BACKGROUND: Ex vivo lung perfusion (EVLP) constitutes a tool with great research potential due to its advantages over in vivo and in vitro models. Despite its important contribution to lung reconditioning, this technique has the disadvantage of incurring high costs and can induce pulmonary endothelial injury through perfusion and ventilation. The pulmonary endothelium is made up of endothelial glycocalyx (EG), a coating of proteoglycans (PG) on the luminal surface. PGs are glycoproteins linked to terminal sialic acids (Sia) that can affect homeostasis with responses leading to edema formation. This study evaluated the effect of two ex vivo perfusion solutions on lung function and endothelial injury. METHODS: We divided ten landrace swine into two groups and subjected them to EVLP for 120 min: Group I (n = 5) was perfused with Steen® solution, and Group II (n = 5) was perfused with low-potassium dextran-albumin solution. Ventilatory mechanics, histology, gravimetry, and sialic acid concentrations were evaluated. RESULTS: Both groups showed changes in pulmonary vascular resistance and ventilatory mechanics (p < 0.05, Student's t-test). In addition, the lung injury severity score was better in Group I than in Group II (p < 0.05, Mann-Whitney U); and both groups exhibited a significant increase in Sia concentrations in the perfusate (p < 0.05 t-Student) and Sia immunohistochemical expression. CONCLUSIONS: Sia, as a product of EG disruption during EVLP, was found in all samples obtained in the system; however, the changes in its concentration showed no apparent correlation with lung function.

Repeated simulation increases belief in the future occurrence of uncertain events.

The feeling that an imagined event will or will not occur in the future - referred to as belief in future occurrence - plays a key role in guiding our decisions and actions. Recent research suggests that this belief may increase with repeated simulation of future events, but the boundary conditions for this effect remain unclear. Considering the key role of autobiographical knowledge in shaping belief in occurrence, we suggest that the effect of repeated simulation only occurs when prior autobiographical knowledge does not clearly support or contradict the occurrence of the imagined event. To test this hypothesis, we investigated the repetition effect for events that were either plausible or implausible due to their coherence or incoherence with autobiographical knowledge (Experiment 1), and for events that initially appeared uncertain because they were not clearly supported or contradicted by autobiographical knowledge (Experiment 2). We found that all types of events became more detailed and took less time to construct after repeated simulation, but belief in their future occurrence increased only for uncertain events; repetition did not influence belief for events already believed or considered implausible. These findings show that the effect of repeated simulation on belief in future occurrence depends on the consistency of imagined events with autobiographical knowledge.

Smartphones dependency risk analysis using machine-learning predictive models.

Recent technological advances have changed how people interact, run businesses, learn, and use their free time. The advantages and facilities provided by electronic devices have played a major role. On the other hand, extensive use of such technology also has adverse effects on several aspects of human life (e.g., the development of societal sedentary lifestyles and new addictions). Smartphone dependency is new addiction that primarily affects the young population. The consequences may negatively impact mental and physical health (e.g., lack of attention or local pain). Health professionals rely on self-reported subjective information to assess the dependency level, requiring specialists' opinions to diagnose such a dependency. This study proposes a data-driven prediction model for smartphone dependency based on machine learning techniques using an analytical retrospective case-control approach. Different classification methods were applied, including classical and modern machine learning models. Students from a private university in Cali-Colombia (n = 1228) were tested for (i) smartphone dependency, (ii) musculoskeletal symptoms, and (iii) the Risk Factors Questionnaire. Random forest, logistic regression, and support vector machine-based classifiers exhibited the highest prediction accuracy, 76-77%, for smartphone dependency, estimated through the stratified-k-fold cross-validation technique. Results showed that self-reported information provides insight into predicting smartphone dependency correctly. Such an approach opens doors for future research aiming to include objective measures to increase accuracy and help to reduce the negative consequences of this new addiction form.

Biomolecules resveratrol + coenzyme Q10 recover the cell state of human mesenchymal stem cells after 1-methyl-4-phenylpyridinium-induced damage and improve proliferation and neural differentiation.

Neurodegenerative disorders are a critical affection with a high incidence around the world. Currently, there are no effective treatments to solve this problem. However, the application of mesenchymal stem cells (MSCs) and antioxidants in neurodegenerative diseases has shown to be a promising tool due to their multiple therapeutic effects. This work aimed to evaluate the effects of a combination of resveratrol (RSV) and coenzyme Q10 (CoQ10) on the proliferation and differentiation of MSC and the protector effects in induced damage. To characterize the MSCs, we performed flow cytometry, protocols of cellular differentiation, and immunocytochemistry analysis. The impact of RSV + CoQ10 in proliferation was evaluated by supplementing 2.5 and 10 µM of RSV + CoQ10 in a cellular kinetic for 14 days. Cell viability and lactate dehydrogenase levels (LDH) were also analyzed. The protective effect of RSV + CoQ10 was assessed by supplementing the treatment to damaged MSCs by 1-methyl-4-phenylpyridinium (MPP+); cellular viability, LDH, and reactive oxygen species (ROS) were evaluated.. MSCs expressed the surface markers CD44, CD73, CD90, and CD105 and showed multipotential ability. The combination of RSV + CoQ10 increased the proliferation potential and cell viability and decreased LDH levels. In addition, it reverted the effect of MPP+-induced damage in MSCs to enhance cell viability and decrease LDH and ROS. Finally, RSV + CoQ10 promoted the differentiation of neural progenitors. The combination of RSV + CoQ10 represents a potential treatment to improve MSCs capacities and protect against neurodegenerative damage.

Impacto medioambiental y socioeconómico en la salud generado por la minería artesanal del oro en Colombia

Introducción: Este artículo de revisión sistemática describe el impacto medioambiental y socioeconómico en salud generado por la minería artesanal del oro en Colombia. Para el estudio se tuvieron en cuenta artículos publicados entre 2010 y 2019. El objetivo de esta revisión bibliográfica fue describir el impacto medioambiental y socioeconómico en la salud generado por la minería artesanal del oro en Colombia. Materiales y métodos: Trabajo construido mediante revisión sistemática, usando los siguientes descriptores: minería, sector informal, riesgo a la salud, condiciones de salud. Para esta búsqueda se utilizaron las bases de datos Scopus, Web of Science, ProQuest, Publindex, así como la normatividad colombiana. Resultados: Se desarrollan las categorías ambientales, socioeconómico y salud. En la categoría ambiental se detalla información sobre sostenibilidad ambiental, manejo de vertimientos, pruebas fisicoquímicas y control gubernamental; En la categoría socioeconómica se describen los dilemas entre minería y medio ambiente, el dilema entre pequeña minería o artesanal y minería a gran escala o industrializada, y el conflicto social y económico. En la categoría salud se analizan las afectaciones y la percepción de la población sobre los daños en la salud, la protección laboral, la innovación social y las oportunidades de cambio para una producción más limpia y saludable. Conclusiones: Los estudios realizados se concentran principalmente en el departamento de Antioquia evidenciando la necesidad de realizar investigaciones en otras zonas del país. A pesar de que en Colombia existe legislación minera, se requiere que el gobierno establezca medidas efectivas de control, capacite y socialice a los mineros sobre métodos adecuados de procesamiento del oro, garantizado el desarrollo ambiental, social y protección laboral.

Introduction: This systematic review article describes the environmental and socioeconomic impact on health generated by handmade gold mining in Colombia. For this study articles published between 2010 and 2019 were considered. The objective of this bibliographic review is to describe the environmental and socioeconomic impact on health generated by gold mining in Colombia. Materials and methods: Work constructed through systematic review, using the following descriptors: mining, informal sector, health risk, health conditions. For this search, Scopus, Web of Science, ProQuest, Publindex databases were used, as well as Colombian regulations. Results: The environmental, socioeconomic, and health categories were developed. In the environmental category, information on environmental sustainability, management of discharges, physicochemical tests, and government control is detailed. In the socioeconomic category, the dilemmas between mining and the environment are described, the dilemma between small or artisanal mining and large-scale or industrialized mining, and the social and economic conflict. In the third category, health, the effects and perception of the population regarding health damage, labor protection, social innovation, and opportunities for change for cleaner and healthier production are analyzed. Conclusions: The studies carried out are mainly concentrated in the department of Antioquia, showing the need to carry out research in other areas of the country. Although there is mining legislation in Colombia, the government is required to establish effective control measures, train, and socialize the miners on adequate gold processing methods, guaranteeing the environmental and social development and protection of its miners.

Inactivación del virus Zika con medio de transporte de ácidos nucleicos, potencialmente aplicable a muestras clínicas para el diagnóstico molecular de SARS-CoV-2 / Inactivation of Zika virus with nucleic acids transport media, potentially applicable to clinical samples for the molecular diagnosis of SARS-CoV-2

RESUMEN Introducción: Los medios de colecta de muestras clínicas con capacidad de desnaturalizar virus reducen los riesgos de contagio durante el transporte y procesamiento. Objetivo: Emplear el medio de transporte de ácidos nucleicos (TAN) en muestras de exudado nasofaríngeo colectadas para el diagnóstico de SARS-CoV-2. Métodos: Se realizó un estudio experimental para demostrar la capacidad del medio de inactivar la infectividad viral. Se tomó como modelo de virus envuelto el virus Zika (VZk), cuyo nivel de bioseguridad es 2. Se evaluó el desempeño clínico del medio TAN para el diagnóstico de SARS-CoV-2. Se empleó una cepa del VZk propagada en la línea celular Vero y, previo a la infección de las células, el VZk se puso en contacto a intervalos de tiempo diferentes (2; 15 y 30 min) con el medio TAN puro; y luego se realizaron diluciones seriadas (10-1-10-4). La inactivación viral se evaluó por RT-PCR, en el sobrenadante y células colectadas, al culminar el periodo de propagación. El desempeño clínico del medio TAN se estimó tomando como referencia el CITOSWAB® VTM, en 30 exudados nasofaríngeos colectados para diagnóstico de la infección por SARS-CoV-2. Resultados: El VZk preservó su infectividad a diluciones del inóculo ≥ 10-2, independientemente del tiempo de contacto. La sensibilidad y especificidad clínica del medio TAN para el diagnóstico de SARS-CoV-2 fueron del 100 %, respectivamente. Conclusiones: Los resultados sugieren que muestras clínicas positivas a VZk en diluciones ≤ 10-1 del medio TAN pueden ser manipuladas de forma segura, lo que pudiera aplicarse potencialmente al diagnóstico molecular del SARS-CoV-2.

ABSTRACT Introduction: Collection media of clinical samples with the capacity to denature viruses reduce the risk of contagion during transportation and processing. Objective: To use the nucleic acids transport media (NATM) in nasopharyngeal swab samples collected for the diagnosis of SARS-CoV-2. Methods: An experimental study was conducted to demonstrate the medium capacity to inactivate viral infectivity. Zika virus (ZIKV), of biosafety level 2, was used as an enveloped virus model. The clinical performance of the NATM for the diagnosis of SARS-CoV-2 was evaluated. A ZIKV strain propagated in the Vero cell line was used and, prior to cells infection, ZIKV was in contact at different intervals (2; 15, and 30 min) with pure NATM; subsequently, serial dilutions (10-1-10-4) were performed. Viral inactivation was evaluated by RT-PCR in the supernatant and the collected cells when the propagation period was completed. CITOSWAB® VTM was used as reference to estimate the clinical performance of the NATM in 30 nasopharyngeal swabs collected for the diagnosis of SARS-CoV-2 infection. Results: ZIKV remained infectious at inoculum dilutions of ≥ 10-2, regardless of contact time. Clinical specificity and sensitivity of the NATM for the diagnosis of SARS-CoV-2 were 100%, respectively. Conclusions: Results suggest that ZIKV positive clinical samples at dilutions ≤ 10-1 of the NATM can be safely handled, which could potentially be applied to the molecular diagnosis of SARS-CoV-2.

Latin American Nursing and Its Social and Cultural Resignification / La enfermería latinoamericana y su re-significación social y cultural / A enfermagem latino-americana e sua ressignificação social e cultural

The article reflects on the importance of leadership and empowerment in Latin American nursing as a collective body responsible for participating in and making public health and health worker policies. For this, it spotlights the contribution that nursing, as a discipline based on research and theory, makes to knowledge, which relies upon the evidence of care in the health-disease process of individuals, families, and groups. It also posits the region's nurse shortage issue, the unequal recognition of nursing as a human care profession, and the need for action and prominence to face the challenge of redefining it.

El artículo aborda una reflexión sobre la importancia del liderazgo y empoderamiento de la enfermería Latinoamericana como cuerpo colectivo, que tiene una responsabilidad en la participación y construcción de la política pública de salud y su talento humano, a partir de la visibilizacion del aporte que, como disciplina fundamentada en investigación y teoría, realiza al conocimiento basado en evidencia del cuidado de los proceso de salud enfermedad de los individuos familias y colectivos. Plantea, además, la problemática de escasez de profesionales de enfermería en la región, la inequidad en el reconocimiento de su valor como profesión del cuidado humano y la necesidad de acción y protagonismo para enfrentar los desafíos de una real re- significación de la profesión.

Este artigo aborda uma reflexão sobre a importância da liderança e empoderamento da enfermagem latino-americana como corpo coletivo que tem uma responsabilidade na participação e construção da política pública de saúde e seu talento humano. Isso a partir da visibilização da contribuição que a enfermagem, como disciplina fundamentada na pesquisa e na teoria, dá ao conhecimento, o qual está baseado na evidência do cuidado dos processos de saúde-doença dos indivíduos, das famílias e dos coletivos. Além disso, propõe-se que a problemática da escassez de profissionais de enfermagem na região, a inequidade no reconhecimento de seu valor como profissão do cuidado humano e a necessidade de ação e protagonismo para enfrentar os desafios de uma real ressignificação da profissão.

Estrategia educativa intercultural para la prevención del cáncer de cuello cérvico uterino en el resguardo de Paujil, Amazonia Colombiana / Intercultural educational strategy for the prevention of cervical cancer in Paujil Resguardo Amazonía colombiana

RESUMEN Los pueblos indígenas siguen sufriendo inequidades, a pesar de los avances relacionados con la protección de la diversidad étnica y cultural, siendo las mujeres uno de los grupos de mayor riesgo, sobre todo, en lo referente a la salud sexual y reproductiva, situación contemplada como un compromiso de acción en los objetivos de desarrollo sostenible. En ese contexto, esta investigación acción participativa buscó construir una estrategia educativa intercultural, sostenible y segura culturalmente que, a propósito de la prevención del cáncer de cuello uterino, aportará al empoderamiento y la conservación de la salud de las mujeres habitantes del resguardo de Paujil -Colombia. La iniciativa surgió de mujeres indígenas preocupadas por mejorar la salud de sus congéneres y un grupo de investigadores. La construcción de una estrategia educativa intercultural representa un reto, pues la pedagogía occidental no necesariamente corresponde a las concepciones de enseñanza aprendizaje de las indígenas del resguardo. Hay dificultades lingüísticas, pues cada etnia tiene su propia lengua. Las indígenas lideresas se convirtieron en las facilitadoras del proceso que se centró más en el uso de la oralidad y encuentros entre mujeres, que se conocen entre sí. Las mujeres prefieren estrategias didácticas basadas en compartir experiencias y el uso de cartillas y videos. El trabajo permitió concluir que cualquier estrategia educativa intercultural que se proponga debe ser específica y acorde a las necesidades de las comunidades.

ABSTRACT Despite the advances related to the protection of ethnic and cultural diversity, indigenous people continue to suffer inequities, with women being one of the groups most at risk, especially concerning sexual and reproductive health, a situation considered as a problem, a commitment to action in the sustainable development goals. In this context, this Participatory action research searched to build an intercultural educational strategy, sustainable and culturally safe, which, concerning the prevention of cervical cancer, would contribute to the empowerment and conservation of the health of the women who live in the Paujil reservation-Colombia. The initiative arose from indigenous women concerned about improving the health of their peers, and a group of researchers. The construction of an intercultural educational strategy represents a challenge since western pedagogy does not necessarily correspond to the teaching-learning conceptions of the indigenous people of the reservation. There are linguistic difficulties because each ethnic group has its language. The indigenous leaders became the facilitators of the process that focused more on the use of orality and meetings between women who know each other. Women prefer a didactic strategy based on sharing experiences, and the use of primers, and videos. The work allowed to conclude that any proposed of intercultural educational strategy must be specific and according to the needs of the communities.

A nutrition education intervention to improve eating behaviors of children with autism spectrum disorder: Study protocol for a pilot randomized controlled trial.

Autism spectrum disorder (ASD) is a developmental disorder that affects communication and social behaviors. Children with ASD often experience mealtime behavior challenges and selective eating behaviors. They also tend to consume fewer fruits and vegetables and more high-energy dense foods, compared to neurotypical peers. A nutrition intervention was designed to prevent the development of feeding disorders and the long-term negative health impacts associated with poor dietary intake. This randomized controlled trial will evaluate the feasibility and preliminary efficacy of the nutrition education intervention for children with ASD and their parents through the Early Intervention (EI) services. We will recruit EI providers and parent-child dyads (n = 48) from EI programs, and randomly assign them into Autism Eats intervention (n = 24) or enhance usual care (EUC) comparison group (n = 24). The Autism Eats is 10 weekly sessions delivered individually as part of EI, while the EUC group will receive only 1 nutrition education session and then weekly parent handouts. The Autism Eats integrates ASD-specific feeding strategies and behaviorally-focused intervention strategies such as goal setting. Feasibility indicators include reach/participation, attrition, completion, fidelity, compatibility, and qualitative participant feedback. Outcome measures include dietary intakes and mealtime behaviors of children with ASD using 3-day food records and a validated questionnaire, the Brief Autism Mealtime Behavior Inventory (BAMBI). We will examine whether there are differences in children's food intakes, variety, diet quality, and mealtime behaviors between Autism Eats and EUC groups at post-intervention and 5-month follow-up assessment. This study will provide critical data to inform a full-scale randomized controlled trial.

Trends Assessing Neuromuscular Fatigue in Team Sports: A Narrative Review.

Neuromuscular fatigue is defined as a reduction induced by exercise in the maximal voluntary force that a muscle or group of muscles can generate. An accumulation of work or an incomplete force restoration can significantly influence the neuromuscular performance in both the short and long terms. Thus, fatigue management is essential for controlling the training adaptations of athletes and reducing their susceptibility to injury and illness. The main individualized monitoring tools used to describe fatigue are questionnaires and subjective assessments of fatigue, biochemical markers, sprint tests, and vertical jump tests. Among the subjective measures, the rating of the perceived exertion has been widely used because of its simplicity and high validity. In terms of the objective measures, one of the more frequently employed tools by practitioners to assess neuromuscular fatigue is the countermovement jump. Because of its high validity and reliability, it is accepted as the reference standard test in sports, in general, and particularly in team sports. Our review aims to clarify how all these indicators, as well as several devices, can help coaches in different sports contexts to monitor neuromuscular fatigue, and how these procedures should be used to obtain data that can be used to make decisions in complex environments.

Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers during Ex Vivo Lung Perfusion with Prolonged Hypothermic Lung-Sparing.

Lung transplantation requires optimization of donor's organ use through ex vivo lung perfusion (EVLP) to avoid primary graft dysfunction. Biomarkers can aid in organ selection by providing early evidence of suboptimal lungs during EVLP and thus avoid high-risk transplantations. However, predictive biomarkers of pulmonary graft function such as endothelin-converting enzyme (ECE-1) and vascular endothelial growth factor (VEGF) have not been described under EVLP with standard prolonged hypothermic preservation, which are relevant in situations where lung procurement is difficult or far from the transplantation site. Therefore, this study is aimed at quantifying ECE-1 and VEGF, as well as determining their association with hemodynamic, gasometric, and mechanical ventilatory parameters in a swine model of EVLP with standard prolonged hypothermic preservation. Using a protocol with either immediate (I-) or delayed (D-) initiation of EVLP, ECE-1 levels over time were found to remain constant in both study groups (p > 0.05 RM-ANOVA), while the VEGF protein was higher after prolonged preservation, but it decreased throughout EVLP (p > 0.05 RM-ANOVA). Likewise, hemodynamic, gasometric, mechanical ventilatory, and histological parameters had a tendency to better results after 12 hours of hypothermic preservation in the delayed infusion group.

Seroprevalence of the SARS-CoV-2 antibody in healthcare workers: a multicentre cross-sectional study in 10 Colombian cities.

BACKGROUND: Healthcare workers are at increased risk of infection due to occupational exposure to SARS-CoV-2-infected patients. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia. METHODS: This study is a cross-sectional study focused on estimating the seroprevalence of SARS-CoV-2 antibodies in healthcare workers from 65 hospitals in 10 cities in Colombia during the second semester of 2020. The seroprevalence was determined using an automated immunoassay (Abbott SARS-CoV-2 CLIA IgG). The study included a survey to establish the sociodemographic variables and the risk of infection. A multivariate model was used to evaluate the association between the results of seroprevalence and risk factors. RESULTS: The global seroprevalence of antibodies against SARS-CoV-2 was 35% (95% Bayesian CI 33% to 37%). All the personnel reported the use of protective equipment. General services personnel and nurses presented the highest ratios of seroprevalence among the healthcare workers. Low socioeconomic strata have shown a strong association with seropositivity. CONCLUSION: This study estimates the prevalence of SARS-CoV-2 infection among healthcare workers. Even though all the personnel reported the use of protective equipment, the seroprevalence in the general services personnel and nurses was high. Also, a significant difference by cities was observed.

Phylogeography of high Andean killifishes Orestias (Teleostei: Cyprinodontidae) in Caquena and Lauca sub-basins of the Altiplano (Chile): mitochondrial and nuclear analysis of an endangered fish.

From the early Miocene, the uplift of the Andes Mountains, intense volcanic activity and the occurrence of successive periods of dryness and humidity would have differentially influenced the modification of Altiplano watersheds, and consequently the evolutionary history of the taxa that live there. We analyzed Orestias populations from the Caquena and Lauca Altiplanic sub-basins of northern Chile to determine their genetic differentiation and relationship to their geographical distribution using mitochondrial (D-loop) and nuclear (microsatellite) molecular markers and to reconstruct its biogeographic history on these sub-basins. The results allowed reconstructing and reevaluating the evolutionary history of the genus in the area; genic diversity and differentiation together with different founding genetic groups suggest that Orestias have been spread homogeneously in the study area and would have experienced local disturbances that promoted isolation and diversification in restricted zones of their distribution.

Comprehensive Evaluation of Primary Care Sports Medicine Fellowship Websites.

OBJECTIVE: To evaluate the comprehensiveness of primary care sports medicine fellowship websites and identify potential areas of improvement. DESIGN: Cross-sectional analysis of fellowship program websites using quantitative and descriptive statistics. SETTING: Internet. PARTICIPANTS: A total of 192 primary care sports medicine fellowship websites listed on the Electronic Residency Application Service (ERAS) website. INDEPENDENT VARIABLES: Program Specialty and Program Region. MAIN OUTCOME MEASURES: The presence or absence of 19 predetermined criteria on primary care sports medicine fellowship websites. RESULTS: The average number of criteria that was included on each website was 9.8 (SD 3.5) (51.6%) of the possible 19. Programs had as few as 2 of the 19 (10.5%) criteria included on their website, and others had as many as 17 of the 19 (89.4%) criteria. Of the 192 primary care sports medicine fellowships, only 5 (2.6%) addressed at least 80% of the 19 different criteria. No primary care sports medicine fellowship website included all 19 criteria. CONCLUSIONS: Most primary care sports medicine fellowship websites do not offer comprehensive information about their programs for prospective applicants.

Effect of Endometrial Sampling Procedures on Subsequent Pregnancy Rate of Cattle.

Endometrial infections are a common cause of reproductive loss in cattle. Accurate diagnosis is important to reduce the economic losses caused by endometritis. A range of sampling procedures have been developed which enable collection of endometrial tissue or luminal cells or uterine fluid. However, as these are all invasive procedures, there is a risk that sampling around the time of breeding may adversely affect subsequent pregnancy rate. This systematic review compared the pregnancy rates (PR) of cattle which underwent uterine lavage (UL), cotton swab (CS), cytobrush (CB), cytotape (CT), or endometrial biopsy (EB) sampling procedures with those that were not sampled. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol, relevant databases, including Pubmed, Web of Science, CAB Abstracts, VetMed Resource-Ruminants, and Scopus, were searched. The outcome measured was the pregnancy rate after the collection of endometrial sample(s). Seven studies, involving a total of 3693 cows, fulfilled the inclusion criteria for the systematic review and allowed the comparison of PR between sampled (n = 1254) and non-sampled cows (n = 2409). The results of the systematic review showed that endometrial sampling procedures can be performed before breeding or shortly after insemination without adversely affecting pregnancy rates in cattle. However, further studies are needed to validate this information.

Loss of Znt8 function in diabetes mellitus: risk or benefit?

The zinc transporter 8 (ZnT8) plays an essential role in zinc homeostasis inside pancreatic ß cells, its function is related to the stabilization of insulin hexameric form. Genome-wide association studies (GWAS) have established a positive and negative relationship of ZnT8 variants with type 2 diabetes mellitus (T2DM), exposing a dual and controversial role. The first hypotheses about its role in T2DM indicated a higher risk of developing T2DM for loss of function; nevertheless, recent GWAS of ZnT8 loss-of-function mutations in humans have shown protection against T2DM. With regard to the ZnT8 role in T2DM, most studies have focused on rodent models and common high-risk variants; however, considerable differences between human and rodent models have been found and the new approaches have included lower-frequency variants as a tool to clarify gene functions, allowing a better understanding of the disease and offering possible therapeutic targets. Therefore, this review will discuss the physiological effects of the ZnT8 variants associated with a major and lower risk of T2DM, emphasizing the low- and rare-frequency variants.

Implementación de técnicas de reproducción asistida en el Centro de Reproducción Humana de la Universidad de Valparaíso: resultados del primer trienio (2015 - 2017) / Implementation of assisted reproduction techniques at the Center of Human Reproduction of the Universidad de Valparaíso: results of the first triennium (2015 - 2017)

INTRODUCCIÓN Y OBJETIVOS: La infertilidad es una enfermedad altamente prevalente que afecta aproximadamente a un 8-10% de las parejas en edad reproductiva. Las Técnicas de Reproducción Asistida (TRA) han experimentado un importante incremento en el número de tratamientos realizados, no obstante, el acceso en Chile sigue siendo limitado y centralizado. El presente estudio resume la experiencia y los resultados de TRA del primer trienio del Centro de Reproducción Humana de la Universidad de Valparaíso (CRHUV). MÉTODOS: Estudio de cohorte retrospectiva de las pacientes sometidas a TRA en el CRHUV desde 1 de enero de 2015 a 31 diciembre 2017. Se realizó un análisis descriptivo e inferencial. La distribución de variables fue analizada con la prueba de Shapiro-Wilk. Para variables cualitativas se usó la prueba exacta de Fisher. RESULTADOS: Se iniciaron un total de 581 ciclos. Para un total de 340 ciclos en fresco con ovocitos propios, la tasa de embarazo (TE) y de parto (TP) por ciclo aspirado fue de 43,5% y 36,7% respectivamente. En el mismo grupo, la TE y TP por transferencia embrionaria fue de un 48,4% y un 40,9% respectivamente, siendo superior al comparar transferencia doble con un embrión (p < 0,05). También se observó un aumento de TE en menores de 35 años (p < 0,05). La TE y TP por transferencia embrionaria fue semejante en transferencia de embriones frescos y congelados. Al transferir embriones producto de ovocitos donados se observó un incremento significativo de la TE y TP con tasas de 73,1% y 61,5% respectivamente. Las tasa globales y estratificadas de embarazo y parto fueron comparables en el trienio estudiado con los resultados de la REDLARA. CONCLUSIÓN: La exitosa implementación del CRHUV se respalda en los resultados comparables a lo reportado por literatura internacional.

INTRODUCTION AND OBJECTIVES: Infertility is a highly prevalent disease that affects approximately 8-10% of couples in reproductive age. Assisted reproduction techniques (ART) have experienced a significant increase in the number of treatments performed, however, access in Chile remains limited and centralized. This study summarizes the experience and results of the first triennium of the Center for Human Reproduction of the Universidad de Valparaíso (CRHUV). METHODS: Retrospective cohort study of patients undergoing ART at the CRHUV from January 1, 2015 to December 31, 2017. A descriptive and inferential analysis was performed. The distribution of the variables was analyzed with the Shapiro-Wilk test. For qualitative variables, Fisher's exact test was used. RESULTS: A total of 581 cycles were started. For a total of 340 fresh cycles with own oocytes, the pregnancy (RP) and delivery (DR) rate per oocyte retrival was 43.5% and 36.7%. In the same group, PR and DR per embryo transfer was 48.4% and 40.9%, being higher when comparing double with a single embryo transfer (p <0.05). A higher PR was also observed in < 35 years patients (p <0.05). The PR and DR per embryo transfer was similar using fresh and frozen embryo. In oocytes donation, a significant increase in PR and RD per embryo transfer was observed with rates of 73.1% and 61.5%, respectively. The global and stratified rates of pregnancy and delivery were comparable in the studied triennium compared to the results of REDLARA. CONCLUSION: The successful implementation of the CRHUV is supported by results comparable to those reported by international literature.

Sports in time of COVID-19: Impact of the lockdown on team activity

The COVID-19 pandemic has affected many sectors of our global society since its detection in Wuhan in December 2019, and team sports have been no stranger to this reality. This special article presents a review of the literature exposing the dangers for athletes of this virus, reporting the effects of the pandemic on competitive sport, and making evidence-based recommendations to avoid the consequences of detraining in confined athletes. Furthermore, we present the results of a survey with 361 answers computed from coaches and different staff members from 26 different countries, representing the activity of more than 4500 athletes from all over the world. The aim was to know more teams’ activity during this cessation period. Finally, the article outlines recommendations based on the answers to help teams if a second outbreak of the virus forces massive confinements again, guiding a safe return to sport at any competitive level. (AU)